Medisinsk forskning på cannabis
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FASTING/FOOD/WATER DEPRIVATION and the ENDOCANNABINOID SYSTEM (24)
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Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women
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Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome
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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats
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Effect of rimonabant on oesophageal motor function in man
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Plasticity in vagal afferent neurones during feeding and fasting: mechanisms and significance
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The effects of fasting duration on gastric emptying in man, an exploration of the role of the endocannabinoid system and inter-individual responsiveness
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Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner
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Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids?
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Involvement of the cannabinoid CB1 receptor in modulation of dopamine output in the prefrontal cortex associated with food restriction in rats
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Role of corticosterone in the murine enteric nervous system during fasting
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Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences
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Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Î9-tetrahydrocannabinol (THC)
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Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways
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Type 1 cannabinoid receptor modulates water deprivation-induced homeostatic responses
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Physiological roles for the subfornical organ â A dynamic transcriptome shaped by autonomic state
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Enhanced Glutamatergic Synaptic Plasticity in the Hippocampal CA1 Field of Food Restricted Rats: Involvement of CB1 Receptors
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CB1 receptors into the Prelimbic Cortex modulate food intake in rats
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Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea
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Docosahexaenoic acid-supplementation prior to fasting prevents muscle atrophy in mice
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A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula
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α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility
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Unconventional endocannabinoid signaling governs sperm activation via sex hormone progesterone
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Association between plasma endocannabinoids and appetite in hemodialysis patients: A pilot study
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Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding
FERTILITY/SEXUAL FUNCTION (90)
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Characterization of the Endocannabinoid System in Human Spermatozoa and Involvement of Transient Receptor Potential Vanilloid 1 Receptor in Their Fertilizing Ability
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N-Acylethanolamine Levels and Expression of Their Metabolizing Enzymes during Pregnancy
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Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction
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Cannabinoids and Reproduction: A Lasting and Intriguing History
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From Fertilisation to Implantation in Mammalian PregnancyâModulation of Early Human Reproduction by the Endocannabinoid System
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Endocannabinoids and Human Sperm Cells
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Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle
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Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity
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Endocannabinoids and pregnancy
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An endocannabinoid system is localized to the hypophysial pars tuberalis of Syrian hamsters and responds to photoperiodic changes
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Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation
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Modulation of the novel cannabinoid receptor â GPR55 â during rat fetoplacental development
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Endogenous Cannabinoid Production in the Rat Female Reproductive Tract Is Regulated by Changes in the Hormonal Milieu
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Treatment with tetrahydrocannabinol (THC) prevents infertility in male cystic fibrosis mice
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Effect of capacitation on the endocannabinoid system of mouse sperm
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Effects of the cannabinoid antagonist SR 141716 on sexual and motor behavior in receptive female rats
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Differences in the endocannabinoid system of sperm from fertile and infertile men
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Endocannabinoid signaling in female reproduction
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Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes
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Uncovering a role for endocannabinoid signaling in autophagy in preimplantation mouse embryos
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Minireview: Endocannabinoids and Gonadal Hormones: Bidirectional Interactions in Physiology and Behavior
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Anandamide regulates the expression of GnRH1, GnRH2, and GnRH-Rs in frog testis
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Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines
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The role of endocannabinoids in gonadal function and fertility along the evolutionary axis
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Long-term use of HU210 adversely affects spermatogenesis in rats by modulating the endocannabinoid system
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Anandamide Transforms Noncopulating Rats into Sexually Active Animals
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Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa
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Immunity and early pregnancy events: are endocannabinoids the missing link?
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Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa
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Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism
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Anandamide Levels Fluctuate in the Bovine Oviduct during the Oestrous Cycle
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Embryonic diapause in humans: time to consider?
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Role of the Endocannabinoid System in the Central Regulation of Nonmammalian Vertebrate Reproduction
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Estrogens and Spermiogenesis: New Insights from Type 1 Cannabinoid Receptor Knockout Mice
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Endocannabinoids as markers of sperm quality: hot spots
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Brain Levels of Prostaglandins, Endocannabinoids, and Related Lipids Are Affected by Mating Strategies
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The Endocannabinoid System and Spermatogenesis
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Low 17beta-Estradiol Levels in Cnr1 Knock-Out Mice Affect Spermatid Chromatin Remodeling by Interfering with Chromatin Reorganization
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Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia
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Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity
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Synthetic cannabinoids and potential reproductive consequences
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Of mice and (wo)men: factors influencing successful implantation including endocannabinoids
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Sexuality, heart and chocolate
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Effectiveness of vaginal adelmidrol for treating pelvic visceral discomforts and anxiety: a prospective observational study
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Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level
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A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats
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Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study
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The endocannabinoid anandamide induces apoptosis in cytotrophoblast cells: Involvement of both mitochondrial and death receptor pathways
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Involvement of cannabinoid receptor-1 activation in mitochondrial depolarizing effect of lipopolysaccharide in human spermatozoa
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Endocannabinoids as biomarkers of human reproduction
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The biological networks in studying cell signal transduction complexity: The examples of sperm capacitation and of endocannabinoid system
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Endocannabinoid Regulation in Human Endometrium Across the Menstrual Cycle
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Low anandamide doses facilitate male rat sexual behaviour through the activation of CB1 receptors
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Endocannabinoid signaling in mammalian ovary
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Endocannabinoid Influence on Partner Preference in Female Rats
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Activity of anandamide (AEA) metabolic enzymes in rat placental bed
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Lipidomic approach towards deciphering anandamide effects in rat decidual cell
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The Cannabinoid Receptor 2 Q63R Variant Modulates the Relationship between Childhood Obesity and Age at Menarche
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Endocannabinoid signaling in female reproductive events: a potential therapeutic target?
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Endocannabinoid signaling in female reproductive events: a potential therapeutic target?
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Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta
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Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta
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A role for GPR55 in human placental venous endothelial cells
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Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation
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Endocannabinoid signaling in the stress response of male and female songbirds
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Participation of the endocannabinoid system (ECS) in the weight-gain and sensitization to LPS exposure in a maternal obesity model
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Type 2 cannabinoid receptor contributes to the physiological regulation of spermato-genesis
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Anandamide Reduces the Ejaculatory Threshold of Sexually Sluggish Male Rats: Possible Relevance for Human Lifelong Delayed Ejaculation Disorder
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Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion
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Anandamide restricts uterine stromal differentiation and is critical for complete decidualization
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Sperm Release from the Oviductal Epithelium Depends on Ca2+ Influx Upon Activation of CB1 and TRPV1 by Anandamide
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Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes
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Biphasic effects of anandamide on behavioural responses: emphasis on copulatory behaviour
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Anandamide and Decidual Remodeling: COX-2 oxidative metabolism as a key regulator
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Anandamide acts via kisspeptin in the regulation of testicular activity of the frog, Pelophylax esculentus
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Endocannabinoid Regulation of Neuroendocrine Systems
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Progesterone and Endocannabinoid Interaction Alters Sperm Activation
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Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18
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Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis
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Role of the endocannabinoid system in the control of mouse myometrium contractility during the menstrual cycle
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The endocannabinoid system in the human granulosa cell line KGN
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The endocannabinoid system in the human granulosa cell line KGN
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Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release
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Dynamic of expression and localization of cannabinoid-degrading enzymes FAAH and MGLL in relation to CB1 during meiotic maturation of human oocytes
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Age of Sexual Debut and Cannabis Use in the United States
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The endocannabinoid anandamide impairs in vitro decidualization of human cells
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2-arachidonoylglycerol levels are increased in leukocytospermia and correlate with seminal macrophages
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Intra-VTA anandamide infusion produces dose-based biphasic effects on male rat sexual behavior expression
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Endocannabinoid system in sexual motivational processes: is it a novel therapeutic horizon?
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Developmental Patterns of Adolescent Marijuana and Alcohol Use and Their Joint Association with Sexual Risk Behavior and Outcomes in Young Adulthood
FETAL ALCOHOL SPECTRUM DISORDER (4)
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Reduced expression of brain cannabinoid receptor 1 (Cnr1) is coupled with an increased complementary micro-RNA (miR-26b) in a mouse model of fetal alcohol spectrum disorders
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Gene-Specific Disruption of Endocannabinoid Receptor 1 (cnr1a) by Ethanol Probably Leads to the Development of Fetal Alcohol Spectrum Disorder (FASD) Phenotypes in Japanese Rice Fish (Oryzias latipes) Embryogenesis
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Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
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Prenatal exposure to recreational drugs affects global motion perception in preschool children
FEVER/TEMPERATURE CONTROL (53)
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Pharmacologically induced hypothermia with cannabinoid receptor agonist WIN55, 212-2 after cardiopulmonary resuscitation
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DOSE-DEPENDENT EFFECTS ON VENTILATION AT REST INDUCED BY HIGH DOSES OF CANNABINOIDS IN RATS
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Contribution of Hypothermia and CB(1) Receptor Activation to Protective Effects of TAK-937, a Cannabinoid Receptor Agonist, in Rat Transient MCAO Model
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Î9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice
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Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats
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Î9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice
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Cannabinoid 1 (CB1) receptor mediates WIN55, 212-2 induced hypothermia and improved survival in a rat post-cardiac arrest model
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Determination of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-01 in mouse blood and tissue after inhalation exposure to âbuzzâ smoke by HPLC/MS/MS
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Dissociation of the Pharmacological Effects of THC by mTOR Blockade
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Cannabinoid (CB)1 receptors are critical for the innate immune response to TLR4 stimulation
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Behavioral Responses to Acute and Sub-chronic Administration of the Synthetic Cannabinoid JWH-018 in Adult Mice Prenatally Exposed to Corticosterone
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Improved Cardiac and Neurologic Outcomes With Postresuscitation Infusion of Cannabinoid Receptor Agonist WIN55, 212-2 Depend on Hypothermia in a Rat Model of Cardiac Arrest
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Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat
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Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice
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Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats
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Cannabinoid Type 1 (CB1) Receptors on Sim1-Expressing Neurons Regulate Energy Expenditure in Male Mice
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Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Î9-tetrahydrocannabinol in Sprague-Dawley rats
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Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Î9- tetrahydrocannabinol in Sprague-Dawley rats
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Genetic Dissection of Behavioural and Autonomic Effects of Î9-Tetrahydrocannabinol in Mice
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Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors
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Monoacylglycerol Lipase Regulates Fever Response
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Hypothalamic control of brown adipose tissue thermogenesis
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Neural correlates of cannabidiol and Î9-tetrahydrocannabinol interactions in mice: implications for medical cannabis
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Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2
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Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2
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Hyperthermia and severe rhabdomyolysis from synthetic cannabinoids
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Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
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Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition
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Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge
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Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge
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Use of paracetamol during pregnancy and child neurological development
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JWH-018 impairs sensorimotor functions in mice
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ENP11, a potential CB1R antagonist, induces anorexia in rats
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Endocannabinoids, through opioids and prostaglandins, contribute to fever induced by key pyrogenic mediators
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âSpiceâ Can Really Heat Things Up
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Repeated administration of phytocannabinoid Î9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner
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Role of nociceptin/orphanin FQ in thermoregulation
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Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling
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Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center
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Prostaglandin E2 that triggers fever is synthesized through an endocannabinoid dependent pathway
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A Curious Case of Inhalation Fever Caused by Synthetic Cannabinoid
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Hypothermic activity of acetaminophen involvement of GABAA receptor, theoretical and experimental studies
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Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
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Turning Up the Heat on Endocannabinoid Signaling
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Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder
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α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility
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Behavioral Characterization of Kappa Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats (link to
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Effect of JWH-250, JWH-073 and their interaction on âtetradâ, sensorimotor, neurological and neurochemical responses in mice
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Endocannabinoids, through opioids and prostaglandins, contribute to fever induced by key pyrogenic mediators
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Novel Psychoactive Substances: the pharmacology of stimulants and hallucinogens
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Pharmacological hypothermia: a potential for future stroke therapy?
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Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets
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Thermolytic degradation of synthetic cannabinoids: chemical exposures and pharmacological consequences (link to
FIBROMYALGIA (16)
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The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial
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Emerging therapies for fibromyalgia: an update
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Cannabis Use in Patients with Fibromyalgia: Effect on Symptoms Relief and Health-Related Quality of Life
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Cannabinoids for Treatment of Chronic Non-Cancer Pain a Systematic Review of Randomized Trials
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Clinical implications for cannabinoid use in the rheumatic diseases: potential for help or harm?
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Association of herbal cannabis use with negative psychosocial parameters in patients with fibromyalgia
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Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
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Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
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Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
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Fibromyalgia
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PROGRESS REPORT Compassionate Use of Medical Cannabis Pilot Program Act July 1, 2014 through June 30, 2015
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β-caryophyllene-complexed in β-cyclodextrin Produces Antihyperalgesic Activity in Animal Model for Fibromyalgia
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Expression of the endocannabinoid receptors in human fascial tissue
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Cannabinoids and autoimmune diseases: A systematic review
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Nabilone for the Management of Pain
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Medical Cannabis â another piece in the mosaic of autoimmunity?
FLU/INFLUENZA (3)
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Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection
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Palmitoylethanolamide is a new possible pharmacological treatment for the inflammation associated with trauma
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Î9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2
FRAGILE X SYNDROME (16)
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Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome
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Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA
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Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome
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Pathological plasticity in fragile X syndrome
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Targeting the endocannabinoid system in the treatment of fragile X syndrome
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New insights into the molecular pathophysiology of fragile X syndrome and therapeutic perspectives from the animal model
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Therapeutic approaches for the future treatment of Fragile X
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Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
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Homer Protein-Metabotropic Glutamate Receptor Binding Regulates Endocannabinoid Signaling and Affects Hyperexcitability in a Mouse Model of Fragile X Syndrome
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Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome
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The basolateral amygdala γ-aminobutyric acidergic system in health and disease
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p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus
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Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model
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Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse
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Dissecting the signaling pathways involved in the crosstalk between mGlu5 and CB1 receptors
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Endocannabinoid signaling in social functioning: an RDoC perspective
